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Composed by Anuchit Thepsee JIU Wellness Co., Ltd
Glutathione is a naturally occurring antioxidant that performs three important functions: combating free radicals, detoxifying the liver, and stimulating the immune system.
Its main mechanism is to protect cells from damage by toxins and free radicals, and it helps to change skin color from dark melanin (eumelanin) to lighter pigment (phaeomelanin), which may result in skin whitening.
Glutathione is a tripeptide composed of three amino acids: glutamate, cysteine, and glycine. The body can produce it naturally.
Benefits of Glutathione:
Antioxidant: Slows down cell aging.
Liver Detoxification: Helps the liver eliminate toxins, heavy metals, and overdoses of medications.
Immune Enhancer: Strengthens the body’s defense system against foreign substances.
Skin Benefits: Inhibits tyrosinase enzyme, resulting in a decrease in dark melanin (eumelanin) and an increase in light pink melanin (pheomelanin), often used in beauty products.
Key Mechanisms of Glutathione:
- High-efficiency antioxidant: Glutathione acts like a magnet, attracting and destroying free radicals, heavy metals, and various toxins that enter the body, such as UV radiation, pollution, or certain medications, to prevent cell damage.
- Liver detoxification: Glutathione helps the liver eliminate fat-soluble toxins by converting them into water-soluble substances, making them easier for the body to excrete through the kidneys or intestines.
- Inhibits skin pigmentation (Skin Lightening): This mechanism works by reducing the activity of the enzyme tyrosinase, causing the body to reduce the production of dark melanin (eumelanin) and increase the production of lighter melanin (phaeomelanin), resulting in brighter skin.
- Immune enhancer: It stimulates the activity of white blood cells (lymphocytes) to increase their effectiveness in fighting foreign substances, viruses, and bacteria.
Glutathione is found in high concentrations in the liver and various cells of the body. It helps protect tissues from damage by free radicals and helps boost immunity.
Precautions and Safety
Glutathione is widely used for skin whitening results, but medically, there is no conclusive evidence that oral consumption is effective, and injection carries a risk of serious side effects.
Forms of Glutathione and How It Works
- Oral: Helps increase glutathione levels in the body, but it may take 4-6 weeks to see results. Oral consumption: Often digested in the digestive system, resulting in poor absorption and potentially unclear results.
Reduced Glutathione (L-Glutathione): This is a readily available form that the body can use immediately. The appropriate dosage should be chosen, and it is often taken with precursors such as cysteine to increase glutathione production in the body. - Topical Application: Provides localized results and helps protect the skin from external factors.
- Injectable: Although a side effect is rapid skin whitening, it has not been approved for safety by the Food and Drug Administration (FDA) in Thailand.
Injections: Dangerous and not approved for cosmetic use in Thailand. Severe side effects such as kidney dysfunction or severe allergic reactions may occur.
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Natural Decrease: Glutathione levels in the body decrease with age, stress, and pollution
How to Safely Increase Glutathione Levels:
Eat foods rich in sulfur: such as fish, chicken, eggs, broccoli, garlic, and onions.
Eat fruits and vegetables rich in antioxidants: such as avocados and spinach.
Warning: The use of glutathione for skin whitening should be carefully researched and should be under the guidance of a doctor.
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